Jan 09

This post originally appeared on CLEO BLOG by Frank Kuo and is reproduced with permission from its author.

Figure 1. The realization of the microscopic Stirling engine. Courtesy of V. Blickle and C. Bechinger in Nature Physics doi:10.1038/nphys2163 (2011).

When people mention the word “laser” to you, what is the first thing coming to your mind? Most of us associate lasers to their scary and destructive power, just like how we are educated in the Star Wars movie series. In reality, lasers can be quite gentle and perform very accurate and precise assignments, like micro-machining (Jim has a nice article about it). In fact, laser can be so gentle that researchers have used it to power the world’s smallest Stirling engine, which is composed of single tiny melamine bead (~ 3 um in diameter) in the water bath.

To realize how this ingenious microscopic engine works, we have to step into the phenomenon of optical trapping/tweezers first. Thanks to the detailed illustration on wiki, I can just summarize it in a few sentences — When the laser is tightly focused, or when it has the Gaussian beam intensity distribution, the tiny particle will be trapped in the focus or the center of the Gaussian beam, just like being trapped in a potential well. This is a result of momentum conservation. When the refracted light rays exit the particle, they exert momentum kicks to the particle, and the net result of these kicks is a force that traps the particle at the center of the focus. If the particle is in the focus, this force is zero. If the particle drifts away from the center, the kicks will be imbalanced and a net force will pull it back to the center. This particle behaves exactly like it is in a potential well. The steepness of the well depends on the laser intensity as you might guess it already. And our talented researchers use this technique to power the microscopic engine.

Here is how it goes. Figure 1 shows the comparison of a microscopic Stirling engine with a macroscopic one. As shown in step (1), the bead is trapped in a potential well by a focused laser beam. From step (1) to (2), the laser intensity is increased such that the bead would be confined in a smaller volume due to the steeper potential well. This is similar to moving a piston to squeeze the volume in the chamber. From (2) to (3), the water bath is heated by another NIR laser, and this step is similar to heating a macroscopic chamber. From step (3) to (4), the potential well is relaxed and the work is exerted from the bead to the surrounding, just like in macroscopic world, the gas is pushing the piston to exert work for useful application. From (4) to (1), the NIR laser is turned off, and the bead is cooled down, just like in the traditional Stirling engine, the gas is cooled back to the ambient temperature. Smart and elegant design, isn’t it?

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Dec 13

(From Raydiance Inc)

This post originally appeared on Jim’s CLEO Blog and is reproduced with permission from the author.

As someone who has been trying to design novel ultrafast laser systems for the past eight years, my eyes were drawn to the title “Applications of Ultrafast Lasers” of Dr. Mike Mielke’s talk from Raydiance Inc. from the awesomely overwhelming list of invited speakers at CLEO 2012. Dr. Mielke’s talk is one of a handful in CLEO’s new Application and Technology conference which debuted last year in Baltimore in order to better bridge the gap between fundamental research and product commercialization.

To see what background information I could potentially find, I went to Raydiance’s website to find a wealth of information on micromachining and a host of video shorts of ultrafast laser micromachining in action. They are so pleasing to watch, I couldn’t help embedding many of them in this post.

Micromachinging with ultrafast lasers allows the removal of material without the introduction of heat (see the video above of laser micromachining on a match head without it igniting). Ultrafast lasers therefore give the advantages of laser machining- tailoring submicron features on the workpiece, without thermal collateral damage. For example, if you are going to have your dentist drill a tiny hole in one of your teeth (see the figure below) , you’d rather have her use the 350 fs laser shown in b) rather than 1.4 ns laser in a) in which the heat generated damages and fractures the tooth.

Drilling tooth enamel with a) 1.4 ns 30 J/cm2 laser pulses and b) with 350 fs 3 J/cm2 pulses. From B.C. Stuart et al, LLNL

This is because drilling with the femtosecond pulses relies on an entirely different physical process for removal of material than nanosecond pulses. For long pulses (> 100 ps), photons are absorbed by the material and converted into heat. This eventually fractures, melts, or vaporizes material at (and nearby) the laser focus. On the other hand, if the pulse is fast enough (< 1 ps), the material is removed solely by photo-ionization. Rather than dumping energy into the material, electrons of target molecules are stripped off by the intense electric field of the pulse. No absorption takes place and therefore no heat is generated.

Because the mechanism for material removal using ultrafast pulses does not depend on the material properties as it does for thermal ablation, such as the melting point, conceivably any material can be machined using ultrafast pulses. This has allowed Raydiance to micromachine polymeric materials for manufacturing next-generation vascular stents and microfluidic devices (see the videos below).

(From Raydiance Inc)……..for the full original post click here.

Nov 15

This post originally appeared on CLEO BLOG by Frank Kuo and is reproduced with permission from its author.

Figure 1. An invisibility cloak made by a faceted dodecahedral. This simulation shows that the plane wave can propagate through it without too much distortion and objects can be hidden inside the dodecahedral. Courtesy of Oliver Paul, Yaroslav Urzhumov, Christoffer Elsen, David Smith, and Marco Rahm.

Various forms of metamaterial have generated a lot of scientific attention in the past few decades. Some exciting “potential” applications include the well-publicized invisibility cloak (Thanks to Harry Potter). As you may know already, metamaterial gains its bizarre optical property (such as negative index of refraction) by its internal composition or structure, rather than its original physical property. Most metamaterial has its magic only in specific wavelength region and this wavelength region is correlated to how small you can make the internal structures of the metamaterial. This is exactly why almost all the research on metamaterial focuses on THz region since THz has very long wavelength and we do not need to make the structures awfully small to concoct the magic (I did read some articles about “universal metamaterials”, but it seems a long way to go. Let’s dream of that coming in CLEO 2012).

Digging into more details, you can have 2D or 3D metamaterial depending on your applications. 2D metamaterial – or so called metamaterial tiles (m-tiles) – seems to make a huge leap in guiding the advance in the invisibility cloak and sensing platform. And they are easier to make (through the help of photo-lithography, or micro-machining on the surface). With this powerful combination, a booming in this field seems inevitable. Let us take a peek of its potential application in invisibility cloak first: Continue reading »

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Oct 03

Left: Reflection images of a histopathology slide corresponding to skin tissue using a low-cost, portable, lens-free off-axis holographic microscope. Right: Conventional reflection-mode microscope image of the same specimen using a 4X objective lens (NA: 0.1). Image from Biomedical Optics Express.

This post originally appeared on Jim’s CLEO Blog and is reproduced with permission from the author.

Research performed in the Ozcan group at UCLA holds a unique place in the field of optics and photonics. Besides the typical pursuit of advancing optical technology, another major initiative of this photonics group is solving problems of global world health, particularly in resource-poor countries.

Early September marked a milestone for the UCLA group as they published work on a compact, low-cost (~$100 USD of parts), dual-mode microscope with 2 micron resolution in Biomedical Optics Express (also written up in a recent OSA press release). The key to making such a low-footprint, low-cost, lab-grade device is using holographic microscopy. The image information stored in a hologram (the interference of the reflected or transmitted light from the specimen with a reference beam) requires no lenses, drastically reducing the weight, size, and overall expense of the device. A computer reconstructs the wavefront reflecting from (or transmitting through) the sample instead of a lens (see fig below). The impact to world health will be increased blood-diagnostics, water quality tests, tissue screening and analysis, and other imaging diagnostics in areas where microscopes currently are not available due to cost and/or remoteness of location. Getting more microscopes into the hands of health workers may have large impacts for heading off disease outbreaks as well as treatments for individuals.

The idea of using holograms in microscopy is not new. In fact it was the quest for higher resolution in electron microscopy which prompted Dennis Gabor to devise wavefront reconstruction by holography in 1948. Gabor coined the word “hologram” which translates “whole message” to emphasize the amount of information that is stored in this very special interference pattern. For a brief history of holography from its roots in microscopy, its development through radar, and its boom in mainstream art and media in the 60′s and 70′s , see Jeff Hecht’s 2010 OPN article.

Schematic of the 200 gram microscope developed by the Ozcan group in reflection mode. LD: laser diode, PH: pin hole, BC: Beamsplitting Cube. Note the two AA batteries as the power source as well as for scale. Image from M. Lee, O. Yaglidere, and A. Ozcan, Biomedical Optics Express, 2, 2721 (2011).

What makes the Ozcan group’s work so special is not the use of a fundamentally new technique, but clever and impressive engineering. This holographic microscope is small, inexpensive, and can work in both transmission and reflection mode. The transmission mode of the current device is similar to an earlier work by the Ozcan group- a cell-phone microscope. In the summer of 2010, the UCLA group published work in Lab on a Chip demonstrating a clever attachment to an ordinary cell-phone which could convert it into lab-grade microscope (see the youtube short below). By employing digital holographic microscopy, the group was able to produce a 38 gram attachment without any lenses, lasers, or bulky optics, which when incorporated with the cell phone camera, produced hologram on the cell phone detector array. The idea is that the hologram data would be sent over the same cell phone to the closest hospital/analysis station, a computer would process the hologram to extract the image information, and then the image would be sent back to the same phone, all within seconds of placing the sample to be analyzed into the device.

Though the current device cannot be so easily integrated onto a phone, the additional benefit of reflection-mode operation makes up for its “bulkiness.” By operating in reflection-mode, the new microscope is additionally suited for imaging optically dense media like tissue, something not possible using in-line transmission holography due to spatial distortions in the reference wave…  To read the full original post, click here.

Aug 17

Sketch of Edward Synge's proposed near-field microscope. The red dot denotes the gold nanoparticle. Picture from L. Novotny, Phys. Today, 64, 47 (2011).

This post originally appeared on Jim’s CLEO Blog and is reproduced with permission from the author.

This year may not be a flush for the market but it is looking good for plasmonics. Expansion of the the work shown in CLEO 2011, Postdeadline paper “Nanoantenna-enhanced gas sensing in a single tailored nanofocus,” from Na Liu et al. just took the August cover of Nature Materials. Additionally, plasmonics has had a solid recent run of the main-stream physics circuit after the publication of two Physics Today articles earlier this year in February and July.

The July issue of Physics Today features an article by Lukas Novotny from University of Rochester in which he reviews near-field optics, the broader category where plasmonics resides. Earlier in the year, Mark Stockman of Georgia State University wrote a very accessible and informative article on nanoplasmonics that took the cover of the February issue of Physics Today. The cover shows a 13th century stained glass window of Sainte Chappelle in Paris whose yellow and red brilliance are assumed to come from nanoplasmonic resonances of silver and gold nanoparticles in the glass. The optical effect of how the red changes over the length of the window is said to have purposely been designed to mimic the flowing blood of Christ.

Novotny’s July article also offers a romantic insight into the history of near-field optics and plasmonics. Novotny, recounts how in 1928, Edward Synge wrote a “prophetic letter” to Einstein proposing a near-field microscope (see Figure above) to optically image a biological sample below the diffraction limit. Synge’s proposed microscope, which could not be realized until 1982 (by Dieter Phol’s group at IBM of Switzerland), looks eerily familiar to current techniques used for the development of plasmonic devices and sensing- the use of metallic nanoparticles to generate surface plasmons in order to enhance a probing optical field. The two Physics Today articles are must-reads for those who need a crash-course on plasmonics.

A plasmon is created when the electrons on a metal surface are periodically displaced with respect to the lattice ions by an external, driving, optical field, creating an “electron oscillator”… for the full post click here.

Jun 28

This post originally appeared on CLEO 2011 by Frank Kuo and is reproduced with permission from its author.

Recently, three-dimensional plasmon rulers based on nano-rods are reported on Science. Hopefully, it will be cool weaponry for measuring the structures of the molecules in the near future. Over the past few decades, optical rulers based on different principles emerged from various branches of optical science. At the same time, researchers are trying hard to push each methodology to the limit. Optical Rulers, as a result, attract an army of researchers and spin off fruitful results. A quick summary of them seems to be a fair amount of content for everyone.

First thing first, what does an optical ruler do? Quite straightforward, it measures the dimensions of the molecular structures. For example, what is the distance between two subunits of a hemoglobin protein? What is the height of a membrane protein when measured from the membrane surface? Put into one sentence – optical rulers are aimed to map out the 3D structures of the molecules such that we can use this information to figure out the functionality of the molecules.

First ruler comes to your mind, I guess, will be the technique of X-ray diffraction. It is a true powerful optical ruler. After all, the DNA structure is solved by it, and Nobel Prize acclaims this technique for more than once. It has great resolution ~ 1Å, and you do not have put anything attached to the molecules. However, the pitfall is that, you have to crystallize the molecules which are merely impossible for some molecules, and the crystal forms of the molecules are in general, not the in vivo forms of the molecules. A report on C&EN and JACS beautifully illustrate the structure changes dramatically depending on the environment.

What is the king of in vivo optical ruler? I would say so far it is NMR. It has the resolutions of a few Å, and the algorithm is advanced so much that complex proteins are revealing their true forms (through more advanced multi-dimensional NMR). The principle is very similar to the trick we play with tuning forks. If you hit on one of the forks and bring the other replica close in, you feel the vibration on the second one and actually both will make the same tone without two touching each other. The energy (in terms of sound wave) resonates in these two forks. In NMR, intrinsic atomic spin plays the role of the tuning fork. By incorporate the isotopes (such as 1H 13C and 15N, these atoms have nonzero spins) into the amino acids of the proteins, the spins of these atoms behave like tuning forks with different tones. Imaging if there are two or more isotope atoms close to each other, the energy (in this situation, the microwave qunta) will be transferred between the isotopes (let’s say between 1H and 15N) assuming one of them is excited by microwave. NMR is specialized in measuring this energy transfer. The closer they are the more efficient energy transfer is. This efficiency drops proportional to 1/r^-6, where r is the distance between two spins. Now, if you have many of these isotope atoms located at different amino acids of a protein, you can figure out which isotopes (or more interestingly, which amino acids) are closer to each other. With the help of computer, you can infer the structures of the proteins, much like a complex trigonometry based on the relative positions of the spins.

Figure 1. A typical 2D NMR spectrum. Each blob can be thought as a sign of energy transferring between the spins of some specific hydrogen and nitrogen. By doing this kind of cross mapping, we can figure out the 3D structure of the molecules.

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May 10

This post originally appeared on CLEO 2011 by Frank Kuo and is reproduced with permission from its author.

Just like the movie slogan, “everything that has a beginning has an end” (I should reverse this to make it more suitable for this short blog). Everything that has a terrific end has a new exciting beginning. Indeed, something electrifying is happening across the Atlantic. Every two year, CLEO/Europe EQEC 2011 (22-26 May, Germany) is taking the heat to Europe and once again is looking forward to resonating what we have just completed in CLEO.

For people like me, who doesn’t have the luxurious time and funding to enjoy another wonderful trip, you can easily find the detailed programs in this link. Once you click the link and scrutinize the abstracts, I hope you don’t get trapped. For sure, the conference is loaded with crazy and smart ideas. Here are just some I found:

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May 06

This post originally appeared on CLEO 2011 by Frank Kuo and is reproduced with permission from its author.

Just want to touch a few more fields before we wrap up this amazing CLEO 2011. The truth is, we all learn a lot and we will crave for more soon.

I guess we are by now all familiar with the metamaterials thanks to the powerful broadcasting media and online news. Metamaterials have some complex indices of refractions, which bend the light in a whole new way. Even nature utilizes it. The amazing colors on the butterflies, insects, are all originated from the nanostructures – some variations of metamaterials. However, I realized yesterday, this is OLD news.

Researchers now have something new called (well, new to me) “configurable metamaterials”. Unlike before, a specific metameterial is only suitable for one frequency; nowadays we can tune the properties of them by varying the temperature, through optical pumping, and more. If we use some materials that have strong thermal or optical responses to construct the metamaterials, these phoeneoma can be achieved. The concept seems to be there for quite a while, but it is just thrilling to see the real works have been done.

This morning, Dr. John E. Bowers gave an amazing talk on silicon photonics. I feel like soon in the future, silicon will replace the metallic wires in the computer, become the light source of miniature sizes penetrating to our daily lives, and constitute the cores of our gadgets. Furthermore, the data transmission rate is much higher (with tens of GBs per second, more than enough to watch all channels of HDTV at once), and the heat generation is negligible compared with the computers of modern days.

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May 05

Just wanted to chime in with a nagging note to remind you to plan your post-deadline itinerary before 8 pm. I am going to commit to PDPA-Session I and not try to hop around the standing-room only crowd. I am particularly interested in the supercontinuum generation and frequency-comb work in this session, some of which is pushing into the mid-ir where there are interesting chemicals to identify for spectroscopy and stand-off detection. Other broadband generation in this session has been performed with small waveguides or micro-resonantors- little pocket combs on silicon (see the April 20, post for more details). I will be disappointed to miss the new Applications and Technology Session, particularly the biomedical work. These groups by far always have the coolest pictures, images, and videos. If you can make it to these talks, the first four of PDPB-Session II, be prepared to be blown away by beautiful videos and images that address improving image acquisition rate, penetration depth, and resolution (again, see the April 20, post for more details). Very likely, these  state-of-the-art techniques may be used on you in your lifetime. You can tell your doctor, “I saw this work at CLEO 2011 before you even graduated from med school.”

May 05

This post originally appeared on CLEO 2011 by Frank Kuo and is reproduced with permission from its author.

Attending poster sessions is energetic and adventurous. It is even a great social event. Compared to technical session, you never fall asleep and you can interrupt the presenters whenever you want (How great is this, you simply have a personal tutor at your disposal). In additions, you learn more in less time if your mind is a knowledge sponge.
Forgive me for sampling only today’s poster session. Actually I totally regret I didn’t spend enough time in the last few days for poster sessions. To me, these successfully poster sessions really mark one of the highlights in CLEO 2011. Here are some of them that I got a chance to interrogate the presenters (they were just busy, it was quite hard to squeeze in to ask even one question):
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